containing a piperidine – pyrrolidine sca ff old modulate the b - amyloid aggregation process preserving the monomer species †
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چکیده
DISFARM-Sez. Chimica Generale e Organica Milano, via Venezian 21, 20133 Milano, Ita Molécules Fluorées et Chimie Médicinale, B Paris Saclay, 5 rue Jean-Baptiste Clément, E-mail: [email protected] Protéines et Nanotechnologies en Sciences Univ. Paris-Sud, CNRS, Université Paris Sa Châtenay-Malabry Cedex, France Lancaster University, Division of Biomedica Medicine, Lancaster LA1 4YQ, UK † Electronic supplementary information ( and additional gures and tables. NMR a procedures and characterization of com uorescence-detected ThT binding as uorescence assays. Experimental proced evaluation. See DOI: 10.1039/c6sc03176e Cite this: Chem. Sci., 2017, 8, 1295
منابع مشابه
β-Hairpin mimics containing a piperidine–pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species† †Electronic supplementary information (ESI) available: Computational methods and additional figures and tables. NMR additional data. Description of synthetic procedures and characterization of compounds. Experimental procedure for fluorescence-detected ThT binding assay; representative curves of ThT fluorescence assays. Experimental procedure for TEM studies, CE, and cellular evaluation. See DOI: 10.1039/c6sc03176e Click here for additional data file.
β-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species Sara Pellegrino[a]*, Nicolò Tonali[b], Emanuela Erba[a], Julia Kaffy[b], Myriam Taverna[c], Alessandro Contini[a], Mark Taylor [d] , David Allsop [d] , Maria Luisa Gelmi[a], Sandrine Ongeri[b] , via Venezian 21, 20133 Milano, Italy [b] Molécules Fluorées et Chi...
متن کاملβ-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.
Alzheimer's disease is a neurodegenerative disorder linked to oligomerization and fibrillization of amyloid β peptides, with Aβ1-42 being the most aggregative and neurotoxic one. We report herein the synthesis and conformational analysis of Aβ1-42-amyloid related β-hairpin peptidomimetics, built on a piperidine-pyrrolidine semi rigid β-turn inducer and bearing two small recognition peptide sequ...
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Our molecules of interest were mainly 2-substituted pyrrolidine and piperidine alkaloids containing 1, 3-aminoketone and 1, 3-aminoalcohol units which are of special synthetic interest (Figure 1). Hygrine and norhygrine belong to the class of tropane alkaloids. The rest of the alkaloids are isolated from 60 species of the genus Sedum and are usually referred as Sedum alkaloids which are of imme...
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تاریخ انتشار 2017